High frequency of fluoroquinolone- and macrolide-resistant streptococci among clinically isolated group b streptococci with reduced penicillin susceptibility

Kouji Kimura, Noriyuki Nagano, Yukiko Nagano, Satowa Suzuki, Jun Ichi Wachino, Keigo Shibayama, Yoshichika Arakawa

研究成果: ジャーナルへの寄稿学術論文査読

51 被引用数 (Scopus)

抄録

Objectives: Recently several clinical isolates of Streptococcus agalactiae [also known as group B Streptococcus (GBS)] that have acquired reduced penicillin susceptibility (PRGBS) by amino acid substitutions in the penicillin-binding protein 2X have emerged. The frequency of fluoroquinolone (FQ)- and macrolide-resistant streptococci among PRGBS is not yet known. Methods: Fifty-seven GBS [19 PRGBS and 38 penicillin-susceptible GBS (PSGBS)], isolated from different medical institutions in Japan, were studied. For GBS, the MICs of penicillin G, levofloxacin and erythromycin were determined using the agar dilution method. Nineteen PRGBS were previously confirmed as genetically diverse streptococci by PFGE. Further, the mechanisms underlying penicillin, FQ and macrolide non-susceptibility/resistance were analysed. Results: The frequency of non-susceptibility to FQs among PSGBS was 18.4% (7/38), whereas that among PRGBS was 100% (19/19). The frequency of resistance to erythromycin among PSGBS was 7.9% (3/38), while that among PRGBS was 47.4% (9/19). Statistical significance was determined using Fisher's exact test between reduced penicillin susceptibility and FQ non-susceptibility (P ≤ 0.0001) and macrolide resistance (P = 0.0012). The resistance/non-susceptibility mechanisms among PRGBS were diverse, suggesting that the PRGBS examined were not clonal. Conclusions: PRGBS isolates tend to show resistance to FQs and/or macrolides. Because the drug choice for treating these multidrug-resistant GBS is more limited than that for usual GBS, these strains may present future public health challenges.

本文言語英語
ページ(範囲)539-542
ページ数4
ジャーナルJournal of Antimicrobial Chemotherapy
68
3
DOI
出版ステータス出版済み - 03-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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