High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

Yan Guo, Adam D. Tomich, Christi L. McElheny, Vaughn S. Cooper, Amelia Tait-Kamradt, Minggui Wang, Fupin Hu, Louis B. Rice, Nicolas Sluis-Cremer, Yohei Doi

研究成果: Article

4 引用 (Scopus)

抄録

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

元の言語English
ページ(範囲)1902-1904
ページ数3
ジャーナルEmerging Infectious Diseases
23
発行部数11
DOI
出版物ステータスPublished - 11-2017

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Fosfomycin
Enterococcus faecium
Catalytic Domain
Pharmaceutical Preparations
Vancomycin-Resistant Enterococci
UDP-N-acetylglucosamine transferase

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

これを引用

Guo, Y., Tomich, A. D., McElheny, C. L., Cooper, V. S., Tait-Kamradt, A., Wang, M., ... Doi, Y. (2017). High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium. Emerging Infectious Diseases, 23(11), 1902-1904. https://doi.org/10.3201/eid2311.171130
Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; Wang, Minggui ; Hu, Fupin ; Rice, Louis B. ; Sluis-Cremer, Nicolas ; Doi, Yohei. / High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium. :: Emerging Infectious Diseases. 2017 ; 巻 23, 番号 11. pp. 1902-1904.
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abstract = "Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.",
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Guo, Y, Tomich, AD, McElheny, CL, Cooper, VS, Tait-Kamradt, A, Wang, M, Hu, F, Rice, LB, Sluis-Cremer, N & Doi, Y 2017, 'High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium', Emerging Infectious Diseases, 巻. 23, 番号 11, pp. 1902-1904. https://doi.org/10.3201/eid2311.171130

High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium. / Guo, Yan; Tomich, Adam D.; McElheny, Christi L.; Cooper, Vaughn S.; Tait-Kamradt, Amelia; Wang, Minggui; Hu, Fupin; Rice, Louis B.; Sluis-Cremer, Nicolas; Doi, Yohei.

:: Emerging Infectious Diseases, 巻 23, 番号 11, 11.2017, p. 1902-1904.

研究成果: Article

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T1 - High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

AU - Guo, Yan

AU - Tomich, Adam D.

AU - McElheny, Christi L.

AU - Cooper, Vaughn S.

AU - Tait-Kamradt, Amelia

AU - Wang, Minggui

AU - Hu, Fupin

AU - Rice, Louis B.

AU - Sluis-Cremer, Nicolas

AU - Doi, Yohei

PY - 2017/11

Y1 - 2017/11

N2 - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

AB - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

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Guo Y, Tomich AD, McElheny CL, Cooper VS, Tait-Kamradt A, Wang M その他. High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium. Emerging Infectious Diseases. 2017 11;23(11):1902-1904. https://doi.org/10.3201/eid2311.171130