High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Ryan K. Shields, Eun J. Kwak, Brian A. Potoski, Yohei Doi, Jennifer M. Adams-Haduch, Fernanda P. Silviera, Yoshiya Toyoda, Joseph M. Pilewski, Maria Crespo, A. William Pasculle, Cornelius J. Clancy, M. Hong Nguyen

研究成果: ジャーナルへの寄稿学術論文査読

68 被引用数 (Scopus)

抄録

Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

本文言語英語
ページ(範囲)246-252
ページ数7
ジャーナルDiagnostic Microbiology and Infectious Disease
70
2
DOI
出版ステータス出版済み - 06-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 感染症

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