High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Ryan K. Shields; Eun J. Kwak; Brian A. Potoski; Yohei Doi; Jennifer M. Adams-Haduch; Fernanda P. Silviera; Yoshiya Toyoda; Joseph M. Pilewski; Maria Crespo; A. William Pasculle; Cornelius J. Clancy; M. Hong Nguyen

doi:10.1016/j.diagmicrobio.2010.12.023

High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Ryan K. Shields
, Eun J. Kwak
, Brian A. Potoski
, Yohei Doi
, Jennifer M. Adams-Haduch
, Fernanda P. Silviera
, Yoshiya Toyoda
, Joseph M. Pilewski
, Maria Crespo
, A. William Pasculle
, Cornelius J. Clancy
, M. Hong Nguyen

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

71 被引用数 (Scopus)

抄録

Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

本文言語	英語
ページ（範囲）	246-252
ページ数	7
ジャーナル	Diagnostic Microbiology and Infectious Disease
巻	70
号	2
DOI	https://doi.org/10.1016/j.diagmicrobio.2010.12.023
出版ステータス	出版済み - 06-2011
外部発表	はい

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

SDG 3 すべての人に健康と福祉を

All Science Journal Classification (ASJC) codes

微生物学（医療）
感染症

文献へのアクセス

10.1016/j.diagmicrobio.2010.12.023

他のファイルとリンク

フィンガープリント

「High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Shields, R. K., Kwak, E. J., Potoski, B. A., Doi, Y., Adams-Haduch, J. M., Silviera, F. P., Toyoda, Y., Pilewski, J. M., Crespo, M., Pasculle, A. W., Clancy, C. J., & Nguyen, M. H. (2011). High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagnostic Microbiology and Infectious Disease, 70(2), 246-252. https://doi.org/10.1016/j.diagmicrobio.2010.12.023

Shields, Ryan K. ; Kwak, Eun J. ; Potoski, Brian A. その他. / High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii : Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. In: Diagnostic Microbiology and Infectious Disease. 2011 ; Vol. 70, No. 2. pp. 246-252.

@article{53cee74e896843858e11527f60f6525e,

title = "High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen",

abstract = "Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91\% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40\% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80\% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.",

author = "Shields, \{Ryan K.\} and Kwak, \{Eun J.\} and Potoski, \{Brian A.\} and Yohei Doi and Adams-Haduch, \{Jennifer M.\} and Silviera, \{Fernanda P.\} and Yoshiya Toyoda and Pilewski, \{Joseph M.\} and Maria Crespo and Pasculle, \{A. William\} and Clancy, \{Cornelius J.\} and Nguyen, \{M. Hong\}",

note = "Funding Information: Experiments were conducted in the laboratories of Drs. Nguyen and Clancy at the University of Pittsburgh. The authors would like to thank Randy Smith, Senior Associate Dean of the School of Pharmacy, the University of Pittsburgh School of Pharmacy, and the University of Pittsburgh Department of Medicine for their generous financial support. We are also indebted to Kelley Wasicek and the Department of Pharmacy at the University of Pittsburgh for assistance in completing this study. Finally, we would like to extend our gratitude to Lloyd Clarke for his assistance with data collection and interpretation. Funding Information: Financial Support. The study was funded by the University of Pittsburgh School of Pharmacy and by seed support from the University of Pittsburgh, Department of Medicine to the Transplant Infectious Diseases Program (MHN and CJC). ",

year = "2011",

month = jun,

doi = "10.1016/j.diagmicrobio.2010.12.023",

language = "English",

volume = "70",

pages = "246--252",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "2",

}

Shields, RK, Kwak, EJ, Potoski, BA, Doi, Y, Adams-Haduch, JM, Silviera, FP, Toyoda, Y, Pilewski, JM, Crespo, M, Pasculle, AW, Clancy, CJ & Nguyen, MH 2011, 'High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen', Diagnostic Microbiology and Infectious Disease, vol. 70, no. 2, pp. 246-252. https://doi.org/10.1016/j.diagmicrobio.2010.12.023

High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. / Shields, Ryan K.; Kwak, Eun J.; Potoski, Brian A. その他.
In: Diagnostic Microbiology and Infectious Disease, Vol. 70, No. 2, 06.2011, p. 246-252.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

TY - JOUR

T1 - High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii

T2 - Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

AU - Shields, Ryan K.

AU - Kwak, Eun J.

AU - Potoski, Brian A.

AU - Doi, Yohei

AU - Adams-Haduch, Jennifer M.

AU - Silviera, Fernanda P.

AU - Toyoda, Yoshiya

AU - Pilewski, Joseph M.

AU - Crespo, Maria

AU - Pasculle, A. William

AU - Clancy, Cornelius J.

AU - Nguyen, M. Hong

N1 - Funding Information: Experiments were conducted in the laboratories of Drs. Nguyen and Clancy at the University of Pittsburgh. The authors would like to thank Randy Smith, Senior Associate Dean of the School of Pharmacy, the University of Pittsburgh School of Pharmacy, and the University of Pittsburgh Department of Medicine for their generous financial support. We are also indebted to Kelley Wasicek and the Department of Pharmacy at the University of Pittsburgh for assistance in completing this study. Finally, we would like to extend our gratitude to Lloyd Clarke for his assistance with data collection and interpretation. Funding Information: Financial Support. The study was funded by the University of Pittsburgh School of Pharmacy and by seed support from the University of Pittsburgh, Department of Medicine to the Transplant Infectious Diseases Program (MHN and CJC).

PY - 2011/6

Y1 - 2011/6

N2 - Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

AB - Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

UR - https://www.scopus.com/pages/publications/79955963693

UR - https://www.scopus.com/pages/publications/79955963693#tab=citedBy

U2 - 10.1016/j.diagmicrobio.2010.12.023

DO - 10.1016/j.diagmicrobio.2010.12.023

M3 - Article

C2 - 21353436

AN - SCOPUS:79955963693

SN - 0732-8893

VL - 70

SP - 246

EP - 252

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -

Shields RK, Kwak EJ, Potoski BA, Doi Y, Adams-Haduch JM, Silviera FP その他. High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagnostic Microbiology and Infectious Disease. 2011 6月;70(2):246-252. doi: 10.1016/j.diagmicrobio.2010.12.023