High prevalence and phylogenetic analysis of TT-virus infection in Mongolia

Hideaki Kato, Masashi Mizokami, Tatsunori Nakano, Yutaka Kondo, Bumbein Dashnyam, Tsendsuren Oyunsuren, Ryuzo Ueda

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A novel DNA virus, TT-virus (TTV), was isolated from a post-transfusion hepatitis patient in Japan. The prevalence of TTV infection was investigated among patients with chronic liver disease and normal alanine aminotransferase (ALT) volunteers as controls in Mongolia. Polymerase chain reaction (PCR) was employed to detect TTV DNA using specific primers derived from open reading frame 1 (ORF1) of the TTV genome. Nucleotide sequences of samples positive for TTV DNA were determined. The sequences were analyzed by a molecular evolutionary method. Fifty (60.2%) hepatitis patients and 12 (42.9%) volunteers were positive for TTV DNA. The serum ALT levels did not differ significantly between patients with single TTV infection and without TTV, HBV and HCV infection. Similarly, the serum ALT levels did not differ significantly between controls with and without TTV infection. Dual infection of TTV with either HBV or HCV did not affect the ALT levels of hepatitis patients. The molecular evolutionary tree showed that TTV was a heterogeneous virus and all strains could be divided into three genotypes in Mongolia. A new genotype was identified that was distinct from those previously reported. Copyright (C) 1999 Elsevier Science B.V.

本文言語English
ページ(範囲)171-179
ページ数9
ジャーナルVirus Research
60
2
DOI
出版ステータスPublished - 04-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 癌研究
  • ウイルス学
  • 感染症

フィンガープリント

「High prevalence and phylogenetic analysis of TT-virus infection in Mongolia」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル