History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu, Tetsuya Tsukamoto, Tsutomu Mizoshita

研究成果: Chapter

4 被引用数 (Scopus)

抄録

Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

本文言語English
ホスト出版物のタイトルThe Diversity of Gastric Carcinoma
ホスト出版物のサブタイトルPathogenesis, Diagnosis, and Therapy
出版社Springer Tokyo
ページ3-28
ページ数26
ISBN(印刷版)443121139X, 9784431211396
DOI
出版ステータスPublished - 01-12-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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