HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease

Yoshinao Muro, Yasushi Ogawa, Kazumitsu Sugiura, Yasushi Tomita

研究成果: Article

19 引用 (Scopus)

抄録

Autoantibodies against DFS70/LEDGF, which is also known as an important partner of HIV-1 integrase, are found in 10% of healthy Japanese people, but in only ∼2% of patients with systemic autoimmune disease (SAD). We wished to characterize the association of HLA class II alleles with the presence of autoantibodies against this molecule. MHC class II genes (DR, DQ, and DP alleles) were analyzed by the polymerase chain reaction-sequence specific primer method in 24 individuals with anti-DFS70 antibodies. The frequencies of HLA-DRB1*0410, -DQB1*0402, and -DPB1*0301 were increased in anti-DFS70 Ab-positive patients, while HLA-DQB1*0302 was decreased compared to Japanese controls. All anti-DFS70 Ab-positive individuals expressed at least one HLA-DQB1 allele with an aspartic acid at residue 57. The immunogenetic background of Japanese individuals with anti-DFS70 antibodies differs from that of patients with SAD. HLA class II genes influence the production of anti-DFS70 antibodies among individuals with various clinical manifestations.

元の言語English
ページ(範囲)252-257
ページ数6
ジャーナルJournal of Autoimmunity
26
発行部数4
DOI
出版物ステータスPublished - 01-06-2006

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Autoantibodies
Autoimmune Diseases
Anti-Idiotypic Antibodies
MHC Class II Genes
Alleles
HLA-DRB1 Chains
Immunogenetics
Aspartic Acid
Polymerase Chain Reaction
lens epithelium-derived growth factor
HLA-DQB1 antigen
p31 integrase protein, Human immunodeficiency virus 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

Muro, Yoshinao ; Ogawa, Yasushi ; Sugiura, Kazumitsu ; Tomita, Yasushi. / HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. :: Journal of Autoimmunity. 2006 ; 巻 26, 番号 4. pp. 252-257.
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HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. / Muro, Yoshinao; Ogawa, Yasushi; Sugiura, Kazumitsu; Tomita, Yasushi.

:: Journal of Autoimmunity, 巻 26, 番号 4, 01.06.2006, p. 252-257.

研究成果: Article

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AB - Autoantibodies against DFS70/LEDGF, which is also known as an important partner of HIV-1 integrase, are found in 10% of healthy Japanese people, but in only ∼2% of patients with systemic autoimmune disease (SAD). We wished to characterize the association of HLA class II alleles with the presence of autoantibodies against this molecule. MHC class II genes (DR, DQ, and DP alleles) were analyzed by the polymerase chain reaction-sequence specific primer method in 24 individuals with anti-DFS70 antibodies. The frequencies of HLA-DRB1*0410, -DQB1*0402, and -DPB1*0301 were increased in anti-DFS70 Ab-positive patients, while HLA-DQB1*0302 was decreased compared to Japanese controls. All anti-DFS70 Ab-positive individuals expressed at least one HLA-DQB1 allele with an aspartic acid at residue 57. The immunogenetic background of Japanese individuals with anti-DFS70 antibodies differs from that of patients with SAD. HLA class II genes influence the production of anti-DFS70 antibodies among individuals with various clinical manifestations.

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