How many passes are needed for endobronchial ultrasound-guided transbronchial needle aspiration for sarcoidosis? A prospective multicenter study

Masahide Oki, Hideo Saka, Masahiko Ando, Harunori Nakashima, Akira Shiraki, Yasushi Murakami, Yoshihito Kogure, Chiyoe Kitagawa, Tatsuo Kato

研究成果: ジャーナルへの寄稿学術論文査読

26 被引用数 (Scopus)

抄録

Background: While endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used as an initial diagnostic procedure for pathological confirmation of sarcoidosis, it is unclear how many passes are required to obtain diagnostic materials. Objectives: The aim of this study was to determine the number of needle passes needed for the diagnosis of stage I/II sarcoidosis using EBUS-TBNA. Methods: At three institutions, 109 patients with suspected stage I/II sarcoidosis were recruited and underwent 6 passes of EBUS-TBNA for the main target lesion. Additional EBUS-TBNA for other lesions was permitted. The cumulative yields of needle passes for detecting noncaseating epithelioid cell granulomas were analyzed. Results: A total of 109 patients underwent EBUS-TBNA for 184 lesions. EBUS-TBNA identified specimens containing granulomas in 81 of 92 patients (88%) with a final diagnosis of sarcoidosis. The cumulative yields through the first, second, third, fourth, fifth, and sixth passes for the main target lesion were 63, 75, 82, 85, 86 and 88%, respectively. In the 55 patients that underwent EBUS-TBNA for multiple lesions, the cumulative yields of 2 passes per lesion for 2 lesions (total of 4 passes) and of 4 passes for single lesions were 86 and 84%, respectively (p = 1.00). Conclusions: If rapid on-site cytological evaluation is not available, we recommend at least 4 passes per patient for either single or multiple lesions with EBUS-TBNA for pathological diagnosis of stage I/II sarcoidosis.

本文言語英語
ページ(範囲)251-257
ページ数7
ジャーナルRespiration
95
4
DOI
出版ステータス出版済み - 01-04-2018
外部発表はい

All Science Journal Classification (ASJC) codes

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