How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment: Comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population

Makoto Tsujita, Norihiko Goto, Takayuki Yamamoto, Takahisa Hiramitsu, Koji Nanmoku, Daijo Inaguma, Asami Takeda, Takaaki Kobayashi, Yoshihiro Tominaga, Kunio Morozumi, Kazuharu Uchida, Yoshihiko Watarai

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Background: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. Methods: This study included 73 patients who had undergone renal transplantation at Nagoya Daini Red Cross Hospital at least 6 months previously and had stable renal function for >3 months. Glomerular filtration rates (GFRs) were measured by inulin clearance (mGFR) and compared with estimated cystatin C-based GFRs (eGFRcys), estimated creatinine-based GFRs (eGFRcre) and their average values (eGFRave). Results: mGFR was 43.3 ± 14.1 mL/min/1.73 m2, eGFRcre was 39.6 ± 11.7, eGFRcys was 56.0 ± 17.1, and eGFRave was 47.8 ± 13.7 mL/min/1.73 m2. Serum cystatin C was 1.39 ± 0.37 mg/L and serum creatinine was 1.58 ± 0.51 mg/dL. The correlation coefficients between mGFR and eGFRcre, eGFRcys, and eGFRave were 0.768, 0.831, and 0.841, respectively (P < 0.001, for all).The intraclass correlation coefficients were 0.754, 0.816, and 0.840, respectively (P < 0.001, for all).The mean differences between measured and estimated GFR values were 3.74 mL/min/1.73 m2 with a root-mean square error (RMSE) of 9.06 for eGFRcre, +12.64 with RMSE of 9.48 for eGFRcys, and +4.45 with RMSE of 7.86 for eGFRave. Bland-Altman plots showed that eGFRcys overestimated GFR values compared with mGFR values in most cases and that eGFRave overestimated GFR values in 53 of 73 cases, whereas eGFRcre underestimated the values in 53 of 73 cases. Conclusion: eGFRave may be the best marker to estimate kidney function in Japanese renal transplant recipients with mildly reduced or normal kidney function.

本文言語English
ページ(範囲)130-134
ページ数5
ジャーナルClinical and Experimental Nephrology
18
1
DOI
出版ステータスPublished - 01-01-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学
  • 腎臓病学
  • 生理学(医学)

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