Human adipose tissue-derived mesenchymal stem cells as a novel feeder layer for epithelial cells

Hiroaki Sugiyama, Kazuhisa Maeda, Masayuki Yamato, Ryuhei Hayashi, Takeshi Soma, Yasutaka Hayashida, Joseph Yang, Masayuki Shirakabe, Akifumi Matsuyama, Akihiko Kikuchi, Yoshiki Sawa, Teruo Okano, Yasuo Tano, Kohji Nishida

研究成果: Article査読

25 被引用数 (Scopus)

抄録

We examined a novel human feeder cell layer of mesenchymal stem cells harvested from human adipose tissues. Gene expression analyses and colony-forming assay with human primary epithelial cells showed that the adipose tissue-derived mesenchymal stem cells produced various factors to support epithelial stem/progenitor maintenance and cell growth. Using the mesenchymal stem cells as novel feeder layers, transplantable epithelial cell sheets could be effectively generated ex vivo on temperature-responsive cell-culture surfaces.

本文言語English
ページ(範囲)445-449
ページ数5
ジャーナルJournal of Tissue Engineering and Regenerative Medicine
2
7
DOI
出版ステータスPublished - 10-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 生体材料
  • 生体医工学

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