抄録
Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. Results: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P <.0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P =.0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P =.0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P =.0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. Conclusion: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.
| 元の言語 | English |
|---|---|
| ジャーナル | Transplant Infectious Disease |
| DOI | |
| 出版物ステータス | Accepted/In press - 01-01-2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Transplantation
これを引用
}
Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients : Risk factors and encephalitis. / Miura, Hiroki; Kawamura, Yoshiki; Hattori, Fumihiko; Tanaka, Makito; Kudo, Kazuko; Ihira, Masaru; Yatsuya, Hiroshi; Takahashi, Yoshiyuki; Kojima, Seiji; Sakaguchi, Hirotoshi; Yoshida, Nao; Hama, Asahito; Yoshikawa, Tetsushi.
：: Transplant Infectious Disease, 01.01.2019.研究成果: Article
TY - JOUR
T1 - Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients
T2 - Risk factors and encephalitis
AU - Miura, Hiroki
AU - Kawamura, Yoshiki
AU - Hattori, Fumihiko
AU - Tanaka, Makito
AU - Kudo, Kazuko
AU - Ihira, Masaru
AU - Yatsuya, Hiroshi
AU - Takahashi, Yoshiyuki
AU - Kojima, Seiji
AU - Sakaguchi, Hirotoshi
AU - Yoshida, Nao
AU - Hama, Asahito
AU - Yoshikawa, Tetsushi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. Results: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P <.0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P =.0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P =.0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P =.0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. Conclusion: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.
AB - Background: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. Methods: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. Results: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P <.0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P =.0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P =.0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P =.0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. Conclusion: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.
UR - http://www.scopus.com/inward/record.url?scp=85075071010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075071010&partnerID=8YFLogxK
U2 - 10.1111/tid.13203
DO - 10.1111/tid.13203
M3 - Article
C2 - 31650671
AN - SCOPUS:85075071010
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
ER -