@article{98507d42f18e4a5ab15c7e9b90ef93df,
title = "Human neuroblastoma growth inhibitory factor (h-NGIF), derived from human astrocytoma conditioned meduim, has neurotrophic properties",
abstract = "Investigations on the general characteristics of human astrocytoma cell line NAC-1 revealed neuroblastoma growth inhibitory activity in conditioned medium. Neuroblastoma growth inhibitory factor (NGIF) was partially purified by Econo Q, Econo CM, and Superose 12 column chromatography. The protein is weakly basic with an estimated Mr of 120,000, possibly having an Mr 60,000 dimeric structure. NGIF inhibits the growth of neurobalstoma cell lines but has no effect on morphology nor does it produce any change in the growth of human glioblastoma cell lines. Interstingly, NGIF appears to promote survival and neurite outgrowth of embryonal rat cortical neurons. These neurotrophic properties suggest a role for NGIF in the development of the nervous system.",
author = "Eksioglu, {Yaman Z.} and Junko Iida and Kiyofumi Asai and Takatoshi Ueki and Keiko Nakanishi and Ichiro Isobe and Kazuo Yamagata and Taiiji Kato",
note = "Funding Information: We would like to thank Drs. Ryo Tanaka and mki-hiko Moriyama for constructive discussions in the course of this study and Mark Hodgson for critical reading of the manuscript. This work was supported by the following grants: the Grant-in-Aid for Scientific Research on Priority Areas; for Cancer Research from the Ministry of Education, Science and Culture, Japan; Grant (1A-2) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan; the Japan Health Sciences Foundation; and Japan Research Foundation for Clinical Pharmacology.",
year = "1994",
month = may,
day = "2",
doi = "10.1016/0006-8993(94)91691-8",
language = "English",
volume = "644",
pages = "282--290",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "2",
}