Humoral immunoresponse to varicella-zoster virus pernasally coadministered with Escherichia coli enterotoxin in mice

Takao Tsuji, Kimiyasu Shiraki, Hiroshi Sato, Jiang Yue-Mea, Yasuko Honma, Tetsushi Yoshikawa, Yoshizo Asano

研究成果: Article査読

8 被引用数 (Scopus)

抄録

It is evaluated whether Escherichia coli enterotoxin is useful for induction of immunity to varicella-zoster virus (VZV) as a mucosal adjuvant in mice. When a commercially available live varicella vaccine (Oka strain) and toxin were administered simultaneously via a nasal route three times at 2 or 6 month intervals, an antibody neutralizing VZV was detected in half or all of the mice vaccinated, respectively. The antibody specific to the vaccine strain of VZV reacted to five proteins, molecular weights of which were 110 K, 100 K, 62 K, 54 K and 46 K. These proteins were composed of glycosylated products of all kinds of glycoproteins. These results suggest that although a nasal administration of the vaccine without the adjuvant has little immunogenicity in mice, the simultaneous administration of the live vaccine and the toxin over a long period induces a specific humoral immunity to VZV. Copyright (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)2049-2054
ページ数6
ジャーナルVaccine
18
19
DOI
出版ステータスPublished - 03-04-2000

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 免疫学および微生物学(全般)
  • 獣医学(全般)
  • 公衆衛生学、環境および労働衛生
  • 感染症

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