Hybrid liposomes affect cellular lipid constituents and caveolae structures

Ke Cao, Kouji Tanaka, Yuji Komizu, Keiko Tamiya-Koizumi, Takashi Murate, Ryuichi Ueoka, Mamoru Kyogashima, Jiro Usukura, Takashi Takahashi, Motoshi Suzuki

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

本文言語English
ページ(範囲)1731-1733
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
22
4
DOI
出版ステータスPublished - 15-02-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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