TY - JOUR
T1 - Hybrid liposomes affect cellular lipid constituents and caveolae structures
AU - Cao, Ke
AU - Tanaka, Kouji
AU - Komizu, Yuji
AU - Tamiya-Koizumi, Keiko
AU - Murate, Takashi
AU - Ueoka, Ryuichi
AU - Kyogashima, Mamoru
AU - Usukura, Jiro
AU - Takahashi, Takashi
AU - Suzuki, Motoshi
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. We thank Dr. Mitsuhiro Nakamura of Gifu Pharmaceutical University and Dr. Yoshiko Banno for Gifu University Graduate School of Medicine for the critical discussion.
PY - 2012/2/15
Y1 - 2012/2/15
N2 - We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
AB - We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
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U2 - 10.1016/j.bmcl.2011.12.093
DO - 10.1016/j.bmcl.2011.12.093
M3 - Article
C2 - 22248855
AN - SCOPUS:84862788946
SN - 0960-894X
VL - 22
SP - 1731
EP - 1733
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 4
ER -