Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa, M. Matsumoto, M. Tagaya, K. Kuwabara, R. Hata, N. Handa, R. Fukunaga, K. Kimura, T. Kamada

研究成果: Article査読

130 被引用数 (Scopus)

抄録

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

本文言語English
ページ(範囲)449-452
ページ数4
ジャーナルJournal of Cerebral Blood Flow and Metabolism
11
3
DOI
出版ステータスPublished - 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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