Hypertrophic pachymeningitis: Three adult cases and a review of the literature

Akihiro Ueda, Madoka Ueda, Takateru Mihara, Shinji Ito, Kunihiko Asakura, Tatsuro Mutoh

研究成果: Article

4 引用 (Scopus)

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Hypertrophic pachymeningitis (HP) is thought to have an autoimmune etiology but its precise cause and treatment remains to be elucidated. Here, we report the clinical details and therapeutic responses of 3 patients with HP and reviewed 66 previously reported cases in the literature. Among these patients, headache was the most frequent complaint. Cranial nerve involvement was also frequently observed, with the optic nerve being the most frequently impaired followed by the oculomotor, trochlear, and abducens nerves in frequency. Elevated C-reactive protein levels and erythrocyte sedimentation rates were found in approximately 97% of the patients. Steroids were the most commonly prescribed therapy, but no definite protocols for the standard dose and duration in HP have been proposed thus far. The average initial dose of prednisolone (PSL) was 42.7 mg/day, and the average maintenance dose was 12.4 mg/day in the chronic stage. Recurrence occurred in many patients when the dose of PSL was reduced to under 20 mg/day. Therefore, steroids should be tapered extremely slowly.

元の言語English
ページ(範囲)243-247
ページ数5
ジャーナルClinical Neurology
51
発行部数4
DOI
出版物ステータスPublished - 01-04-2011

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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