Hypo- and hyper alphalipoproteinemia and genetic abnormalities in reverse cholesterol transport system

Akifumi Matsuyama, S. Yamashita

研究成果: Review article

抄録

The risk of atherosclerosis has been known to be inversely correlated with the plasma concentration of high-density lipoprotein (HDL)-cholesterol, and we now know HDL plays a protective role against atherosclerosis. The most important mechanism, by which HDL could exert their anti-atherogenic role, is certainly the removal of excess cholesterol from peripheral cells and its transport to the liver, a process commonly called "reverse cholesterol transport system". In this system, many proteins are involved, i.e., ABC1, LCAT, CETP, HTGL and SR-BI. Abnormalities of these proteins reduce the efficacy of the system, and cause abnormalities of HDL and atherosclerosis. In this paper, we review the recent findings on the molecular mechanism of reverse cholesterol transport system, and then discuss hypo- and hyperalphalipoproteinemia, which are caused by genetic abnormalities of the key players.

元の言語English
ページ(範囲)2729-2734
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
57
発行部数12
出版物ステータスPublished - 01-01-1999

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HDL Lipoproteins
Atherosclerosis
Cholesterol
Hypoalphalipoproteinemias
HDL Cholesterol
Proteins
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

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