Hypokalemic metabolic acidosis attributed to cough mixture abuse

Isao Ito, Yukio Yuzawa, Masashi Mizuno, Kazuhiro Nishikawa, Akira Tashita, Takahito Jomori, Nigishi Hotta, Seiichi Matsuo

研究成果: Article査読

11 被引用数 (Scopus)

抄録

This report describes a patient with mixed normal anion gap hyperchloremic metabolic and respiratory acidosis associated with hypokalemia attributed to cough mixture abuse. Metabolic acidosis was likely related to an overdose of ammonium chloride, whereas respiratory acidosis was probably related to the effect of hypokalemia on respiratory muscles causing hypoventilation. Hypokalemia was caused by a transcellular shift of potassium induced by ephedrine and pseudoephedrine. Both ammonium chloride and ephedrine were probably present in the cough mixture obtained by our patient as an over-the-counter medication. Physicians should be aware of the potential for cough mixture abuse to cause major electrolyte disturbances that may carry the risk for major cardiac arrhythmias, particularly in youth.

本文言語English
ページ(範囲)390-394
ページ数5
ジャーナルAmerican Journal of Kidney Diseases
38
2
DOI
出版ステータスPublished - 01-01-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腎臓病学

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