TY - JOUR
T1 - Identification and characterization of a human G9P[23] rotavirus strain from a child with diarrhoea in Thailand
T2 - Evidence for porcine-to-human interspecies transmission
AU - Komoto, Satoshi
AU - Tacharoenmuang, Ratana
AU - Guntapong, Ratigorn
AU - Ide, Tomihiko
AU - Sinchai, Phakapun
AU - Upachai, Sompong
AU - Fukuda, Saori
AU - Yoshikawa, Tetsushi
AU - Tharmaphornpilas, Piyanit
AU - Sangkitporn, Somchai
AU - Taniguchi, Koki
N1 - Funding Information:
This study was supported in part by the Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development, AMED (S. K. and K. T.), and the Original Rotavirus Vaccine Effectiveness Study Program of the Ministry of Public Health of Thailand (S. S.).
Publisher Copyright:
© 2017 The Authors.
PY - 2017/4
Y1 - 2017/4
N2 - An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8- N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
AB - An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8- N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
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U2 - 10.1099/jgv.0.000722
DO - 10.1099/jgv.0.000722
M3 - Article
C2 - 28382902
AN - SCOPUS:85019123683
VL - 98
SP - 532
EP - 538
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
IS - 4
ER -