Identification and characterization of PDGFR + mesenchymal progenitors in human skeletal muscle

A. Uezumi, S. Fukada, N. Yamamoto, M. Ikemoto-Uezumi, M. Nakatani, M. Morita, A. Yamaguchi, H. Yamada, I. Nishino, Y. Hamada, K. Tsuchida

研究成果: Article査読

137 被引用数 (Scopus)

抄録

Fatty and fibrous connective tissue formation is a hallmark of diseased skeletal muscle and deteriorates muscle function. We previously identified non-myogenic mesenchymal progenitors that contribute to adipogenesis and fibrogenesis in mouse skeletal muscle. In this study, we report the identification and characterization of a human counterpart to these progenitors. By using PDGFR as a specific marker, mesenchymal progenitors can be identified in the interstitium and isolated from human skeletal muscle. PDGFR + cells represent a cell population distinct from CD56 + myogenic cells, and adipogenic and fibrogenic potentials were highly enriched in the PDGFR + population. Activation of PDGFR stimulates proliferation of PDGFR + cells through PI3K-Akt and MEK2-MAPK signaling pathways, and aberrant accumulation of PDGFR + cells was conspicuous in muscles of patients with both genetic and non-genetic muscle diseases. Our results revealed the pathological relevance of PDGFR + mesenchymal progenitors to human muscle diseases and provide a basis for developing therapeutic strategy to treat muscle diseases.

本文言語English
論文番号e1186
ジャーナルCell Death and Disease
5
4
DOI
出版ステータスPublished - 04-2014

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 細胞および分子神経科学
  • 細胞生物学
  • 癌研究

フィンガープリント

「Identification and characterization of PDGFR + mesenchymal progenitors in human skeletal muscle」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル