Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata, Matti Virkkunen, Markku Linnoila, David Goldman

研究成果: Article査読

13 被引用数 (Scopus)

抄録

We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

本文言語English
ページ(範囲)217-220
ページ数4
ジャーナルMolecular Brain Research
58
1-2
DOI
出版ステータスPublished - 15-07-1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞および分子神経科学

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