Identification of a Shiga-toxin type I variant containing an IS1203-like element, from Shiga-toxin producing Escherichia coli O157:H7

Masahiro Suzuki, Fumio Kondo, Yuko Ito, Masakado Matsumoto, Mami Hata, Hisao Oka, Masao Takahashi, Kenji Sakae

研究成果: Article査読

13 被引用数 (Scopus)

抄録

We found two Shiga toxin producing Escherichia coli O157:H7 strains isolated from humans carrying the stx1 gene with an IS1203-like element (designated as IS1203v1). The IS1203v1 was inserted into the coding region of the A subunit 7 bp upstream from the TGA termination codon, resulting in a loss of two amino acid residues (Ser-Ser) from its C terminus. Toxicity of the Stx1 was confirmed by Vero cell assay. IS1203v1 hardly affected the stx1 gene in either its expression or the toxicity of its product.

本文言語English
ページ(範囲)63-67
ページ数5
ジャーナルFEMS Microbiology Letters
234
1
DOI
出版ステータスPublished - 01-05-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 分子生物学
  • 遺伝学

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