Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania

Guo Bao Tian; Jennifer M. Adams-Haduch; Tatiana Bogdanovich; Anthony W. Pasculle; John P. Quinn; Hong Ning Wang; Yohei Doi

doi:10.1128/AAC.01155-10

Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania

Guo Bao Tian
, Jennifer M. Adams-Haduch
, Tatiana Bogdanovich
, Anthony W. Pasculle
, John P. Quinn
, Hong Ning Wang
, Yohei Doi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

抄録

Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored bla_OXA-160, bla _OXA-72, and bla_OXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of bla_OXA-160 and bla _OXA-40 beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.

本文言語	英語
ページ（範囲）	429-432
ページ数	4
ジャーナル	Antimicrobial agents and chemotherapy
巻	55
号	1
DOI	https://doi.org/10.1128/AAC.01155-10
出版ステータス	出版済み - 01-2011
外部発表	はい

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All Science Journal Classification (ASJC) codes

薬理学
薬理学（医学）
感染症

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10.1128/AAC.01155-10

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引用スタイル

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