Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Hiroaki Korekane, Jong Yi Park, Akio Matsumoto, Kazuki Nakajima, Shinji Takamatsu, Kazuaki Ohtsubo, Yasuhide Miyamoto, Shinya Hanashima, Kenji Kanekiyo, Shinobu Kitazume, Yoshiki Yamaguchi, Ichiro Matsuo, Naoyuki Taniguchi

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

本文言語English
ページ(範囲)27912-27926
ページ数15
ジャーナルJournal of Biological Chemistry
288
39
DOI
出版ステータスPublished - 27-09-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

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