Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Hiroaki Korekane; Jong Yi Park; Akio Matsumoto; Kazuki Nakajima; Shinji Takamatsu; Kazuaki Ohtsubo; Yasuhide Miyamoto; Shinya Hanashima; Kenji Kanekiyo; Shinobu Kitazume; Yoshiki Yamaguchi; Ichiro Matsuo; Naoyuki Taniguchi

doi:10.1074/jbc.M113.474304

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Hiroaki Korekane
, Jong Yi Park
, Akio Matsumoto
, Kazuki Nakajima
, Shinji Takamatsu
, Kazuaki Ohtsubo
, Yasuhide Miyamoto
, Shinya Hanashima
, Kenji Kanekiyo
, Shinobu Kitazume
, Yoshiki Yamaguchi
, Ichiro Matsuo
, Naoyuki Taniguchi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

34 被引用数 (Scopus)

抄録

Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

本文言語	英語
ページ（範囲）	27912-27926
ページ数	15
ジャーナル	Journal of Biological Chemistry
巻	288
号	39
DOI	https://doi.org/10.1074/jbc.M113.474304
出版ステータス	出版済み - 27-09-2013

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M113.474304

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引用スタイル

Korekane, H., Park, J. Y., Matsumoto, A., Nakajima, K., Takamatsu, S., Ohtsubo, K., Miyamoto, Y., Hanashima, S., Kanekiyo, K., Kitazume, S., Yamaguchi, Y., Matsuo, I., & Taniguchi, N. (2013). Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb). Journal of Biological Chemistry, 288(39), 27912-27926. https://doi.org/10.1074/jbc.M113.474304

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title = "Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)",

abstract = "Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.",

author = "Hiroaki Korekane and Park, \{Jong Yi\} and Akio Matsumoto and Kazuki Nakajima and Shinji Takamatsu and Kazuaki Ohtsubo and Yasuhide Miyamoto and Shinya Hanashima and Kenji Kanekiyo and Shinobu Kitazume and Yoshiki Yamaguchi and Ichiro Matsuo and Naoyuki Taniguchi",

year = "2013",

month = sep,

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doi = "10.1074/jbc.M113.474304",

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Korekane, H, Park, JY, Matsumoto, A, Nakajima, K, Takamatsu, S, Ohtsubo, K, Miyamoto, Y, Hanashima, S, Kanekiyo, K, Kitazume, S, Yamaguchi, Y, Matsuo, I & Taniguchi, N 2013, 'Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)', Journal of Biological Chemistry, vol. 288, no. 39, pp. 27912-27926. https://doi.org/10.1074/jbc.M113.474304

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T1 - Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

AU - Korekane, Hiroaki

AU - Park, Jong Yi

AU - Matsumoto, Akio

AU - Nakajima, Kazuki

AU - Takamatsu, Shinji

AU - Ohtsubo, Kazuaki

AU - Miyamoto, Yasuhide

AU - Hanashima, Shinya

AU - Kanekiyo, Kenji

AU - Kitazume, Shinobu

AU - Yamaguchi, Yoshiki

AU - Matsuo, Ichiro

AU - Taniguchi, Naoyuki

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

AB - Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

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