Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C.A. Spencer, Bryan Howie, Hin Tak Leung, Annette M. Hartmann, Hans Jürgen Möller, Derek W. Morris, Yong Yong ShiGuo Yin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M. Quinn, Thomas G. Schulze, Nigel M. Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R. Sanders, Douglas F. Levinson, Pablo V. Gejman, Nancy G. Buccola, Bryan J. Mowry, Robert Freedman, Farooq Amin, Donald W. Black, Jeremy M. Silverman, William F. Byerley, C. Robert Cloninger, Sven Cichon, Markus M. Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J. Owen

研究成果: Article

832 引用 (Scopus)

抜粋

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

元の言語English
ページ(範囲)1053-1055
ページ数3
ジャーナルNature Genetics
40
発行部数9
DOI
出版物ステータスPublished - 01-09-2008

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント Identification of loci associated with schizophrenia by genome-wide association and follow-up' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H. T., Hartmann, A. M., Möller, H. J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201