Identification of plexin family molecules in mice

Toshiki Kameyama, Yasunori Murakami, Fumikazu Suto, Atsushi Kawakami, Shin Takagi, Tatsumi Hirata, Hajime Fujisawa

研究成果: Article

37 引用 (Scopus)

抜粋

By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1. Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins. Thus, we named these two proteins mouse plexin 2 and mouse plexin 3. We obtained mouse plexin 3 cDNA clones in which a part of protein-coding region was deleted. Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that, in the mouse, plexins comprise a molecular family (the plexin family).

元の言語English
ページ(範囲)396-402
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
226
発行部数2
DOI
出版物ステータスPublished - 13-09-1996

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., & Fujisawa, H. (1996). Identification of plexin family molecules in mice. Biochemical and Biophysical Research Communications, 226(2), 396-402. https://doi.org/10.1006/bbrc.1996.1367