IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Koji Matsumoto; Toshiharu Yasugi; Akinori Oki; Takuma Fujii; Chisato Nagata; Souei Sekiya; Hiroshi Hoshiai; Yuji Taketani; Tadahito Kanda; Takashi Kawana; Hiroyuki Yoshikawa

doi:10.1016/j.canlet.2005.02.023

IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Koji Matsumoto
, Toshiharu Yasugi
, Akinori Oki
, Takuma Fujii
, Chisato Nagata
, Souei Sekiya
, Hiroshi Hoshiai
, Yuji Taketani
, Tadahito Kanda
, Takashi Kawana
, Hiroyuki Yoshikawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

21 被引用数 (Scopus)

抄録

To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

本文言語	英語
ページ（範囲）	309-313
ページ数	5
ジャーナル	Cancer Letters
巻	231
号	2
DOI	https://doi.org/10.1016/j.canlet.2005.02.023
出版ステータス	出版済み - 18-01-2006
外部発表	はい

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All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.1016/j.canlet.2005.02.023

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title = "IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia",

abstract = "To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.",

author = "Koji Matsumoto and Toshiharu Yasugi and Akinori Oki and Takuma Fujii and Chisato Nagata and Souei Sekiya and Hiroshi Hoshiai and Yuji Taketani and Tadahito Kanda and Takashi Kawana and Hiroyuki Yoshikawa",

note = "Funding Information: We thank Graham R. Leggatt (Centre for Immunology and Cancer Research, University of Queensland, Australia) for helpful discussion. We are also grateful to all the women that participated in this study. This work was supported by the grant (12218102) from the Ministry of Education, Science, Sports and Culture of Japan.",

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doi = "10.1016/j.canlet.2005.02.023",

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T1 - IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

AU - Matsumoto, Koji

AU - Yasugi, Toshiharu

AU - Oki, Akinori

AU - Fujii, Takuma

AU - Nagata, Chisato

AU - Sekiya, Souei

AU - Hoshiai, Hiroshi

AU - Taketani, Yuji

AU - Kanda, Tadahito

AU - Kawana, Takashi

AU - Yoshikawa, Hiroyuki

N1 - Funding Information: We thank Graham R. Leggatt (Centre for Immunology and Cancer Research, University of Queensland, Australia) for helpful discussion. We are also grateful to all the women that participated in this study. This work was supported by the grant (12218102) from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2006/1/18

Y1 - 2006/1/18

N2 - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

AB - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

UR - https://www.scopus.com/pages/publications/29844441096

UR - https://www.scopus.com/pages/publications/29844441096#tab=citedBy

U2 - 10.1016/j.canlet.2005.02.023

DO - 10.1016/j.canlet.2005.02.023

M3 - Article

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AN - SCOPUS:29844441096

SN - 0304-3835

VL - 231

SP - 309

EP - 313

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

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UN SDG

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