IL-32 expression is an independent prognostic marker for gastric cancer

Sumiya Ishigami, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Yoshiaki Kita, Ken Sasaki, Hiroshi Okumura, Hiroshi Kurahara, Yuko Kijima, Aya Harada, Shinichi Ueno, Shoji Natsugoe

研究成果: Article査読

31 被引用数 (Scopus)

抄録

A strong link between inflammation and gastrointestinal cancer has been demonstrated. Interleukin (IL)-32 is a recently described pro-inflammatory cytokine characterized by the induction of nuclear factor kappa B (NF-κB) activation. We investigated whether IL-32 expression has clinical significance in gastric cancer. A total of 182 gastric cancer patients who received curative gastrectomy were enrolled in our study. IL-32 expression was detected by immunohistochemistry, and the correlation between clinicopathological features and IL-32 expression was analyzed. Tumor depth and lymph node metastases developed more frequently in IL-32-positive gastric cancer patients than those who were negative for IL-32 expression (p < 0.01). Lymphatic- and venous invasion in the IL-32-positive group were more severe than in cancer cells lacking IL-32 expression (p < 0.05). Multivariate analysis demonstrated that IL-32 is one of the prognostic markers (p < 0.03) for gastric cancer, in addition to nodal involvement and tumor depth. IL-32 positivity significantly affected clinicopathological factors. Thus, IL-32 expression in gastric cancer may serve as a preferential metastatic condition that allows cells to escape host antitumor immunity. Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells.

本文言語English
論文番号472
ジャーナルMedical Oncology
30
2
DOI
出版ステータスPublished - 06-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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