IL4 from T follicular helper cells downregulates antitumor immunity

Hidekazu Shirota, Dennis M. Klinman, Shuku Ei Ito, Hiroyasu Ito, Masato Kubo, Chikashi Ishioka

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Immune cells constitute a large fraction of the tumor microenvironment and modulate tumor progression. Clinical data indicate that chronic inflammation is present at tumor sites and that IL4 in particular is upregulated. Here, we demonstrate that T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes. These findings suggest that IL4 from Tfh cells affects antitumor immunity and constitutes an attractive therapeutic target to reduce immunosuppression in the tumor microenvironment, and thus enhance the efficacy of cancer immunotherapy.

本文言語English
ページ(範囲)61-71
ページ数11
ジャーナルCancer Immunology Research
5
1
DOI
出版ステータスPublished - 01-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 癌研究

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