Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model

Arata Oh-Nishi, Yuji Nagai, Chie Seki, Tetsuya Suhara, Takafumi Minamimoto, Makoto Higuchi

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET) in vivo imaging and ex vivo neurochemical analyses of cortical D2Rs in MIA. In the micro-PET analyses, the anterior cingulate cortex (ACC) region in the offspring showed significantly reduced binding potential for [11C]FLB457, a high affinity radio-ligand toward D2Rs. Neurochemical analysis showed reduction of D2Rs and augmentation of dopamine turnover in the ACC of the rat offspring. Thus, MIA induces dopaminergic dysfunction in the ACC of offspring, similar to the neuronal pathology reported in patients with schizophrenia.

本文言語英語
論文番号100446
ジャーナルBrain, Behavior, and Immunity - Health
22
DOI
出版ステータス出版済み - 07-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腎臓病学

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