Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands

Jun Maeda, Makoto Higuchi, Tetsuya Suhara

研究成果: ジャーナルへの寄稿総説査読

1 被引用数 (Scopus)

抄録

Recently, it has been indicated that glial cells play as important role in the development of neurodegenerative disorders. Expression of peripheral benzodiazepine receptor (PBR) has higher localization in the glial cells than in the neural cells, and is a noticeable marker for gliosis produced by neurodegeneration. In vivo imaging of PBR has been attempted by [ 11C]PK11195 positron emission tomography (PET), and it has been documented that the [11C]PK11195 binding potential increases in various neurodegenerative disorders such as Alzheimer's disease and stroke. Furthermore, we have succeeded in developing new positron ligands [ 11C]DAA1106 and [18F]fluoroethyl-DAA1106 for visualization of PBRs, which have higher accumulation in the brain than [11C] PK11195. We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders.

本文言語英語
ページ(範囲)17-21
ページ数5
ジャーナルJapanese Journal of Neuropsychopharmacology
26
1
出版ステータス出版済み - 02-2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 臨床心理学
  • 薬理学
  • 精神医学および精神衛生
  • 薬理学(医学)

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