抄録
Recently, it has been indicated that glial cells play as important role in the development of neurodegenerative disorders. Expression of peripheral benzodiazepine receptor (PBR) has higher localization in the glial cells than in the neural cells, and is a noticeable marker for gliosis produced by neurodegeneration. In vivo imaging of PBR has been attempted by [ 11C]PK11195 positron emission tomography (PET), and it has been documented that the [11C]PK11195 binding potential increases in various neurodegenerative disorders such as Alzheimer's disease and stroke. Furthermore, we have succeeded in developing new positron ligands [ 11C]DAA1106 and [18F]fluoroethyl-DAA1106 for visualization of PBRs, which have higher accumulation in the brain than [11C] PK11195. We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders.
本文言語 | 英語 |
---|---|
ページ(範囲) | 17-21 |
ページ数 | 5 |
ジャーナル | Japanese Journal of Neuropsychopharmacology |
巻 | 26 |
号 | 1 |
出版ステータス | 出版済み - 02-2006 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 臨床心理学
- 薬理学
- 精神医学および精神衛生
- 薬理学(医学)