TY - JOUR
T1 - Imaging of tau pathology in a tauopathy mouse model and in alzheimer patients compared to normal controls
AU - Maruyama, Masahiro
AU - Shimada, Hitoshi
AU - Suhara, Tetsuya
AU - Shinotoh, Hitoshi
AU - Ji, Bin
AU - Maeda, Jun
AU - Zhang, Ming Rong
AU - Trojanowski, John Q.
AU - Lee, Virginia M.Y.
AU - Ono, Maiko
AU - Masamoto, Kazuto
AU - Takano, Harumasa
AU - Sahara, Naruhiko
AU - Iwata, Nobuhisa
AU - Okamura, Nobuyuki
AU - Furumoto, Shozo
AU - Kudo, Yukitsuka
AU - Chang, Qing
AU - Saido, Takaomi C.
AU - Takashima, Akihiko
AU - Lewis, Jada
AU - Jang, Ming Kuei
AU - Aoki, Ichio
AU - Ito, Hiroshi
AU - Higuchi, Makoto
PY - 2013/9/18
Y1 - 2013/9/18
N2 - Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer@s disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders. Invivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection oftau inclusions by PBBs. A pyridinated PBB, [11C]PBB3, was next applied in a clinical PET study, and its robust signal in the AD hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [11C]Pittsburgh Compound-B ([11C]PIB). [11C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [11C]PBB3 signals were found in a corticobasal syndrome patient negative for [11C]PIB-PET
AB - Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer@s disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders. Invivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection oftau inclusions by PBBs. A pyridinated PBB, [11C]PBB3, was next applied in a clinical PET study, and its robust signal in the AD hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [11C]Pittsburgh Compound-B ([11C]PIB). [11C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [11C]PBB3 signals were found in a corticobasal syndrome patient negative for [11C]PIB-PET
UR - https://www.scopus.com/pages/publications/84884273839
UR - https://www.scopus.com/pages/publications/84884273839#tab=citedBy
U2 - 10.1016/j.neuron.2013.07.037
DO - 10.1016/j.neuron.2013.07.037
M3 - Article
C2 - 24050400
AN - SCOPUS:84884273839
SN - 0896-6273
VL - 79
SP - 1094
EP - 1108
JO - Neuron
JF - Neuron
IS - 6
ER -