Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

Ana Moraga; Vanessa Gómez-Vallejo; María Isabel Cuartero; Boguslaw Szczupak; Eneko San Sebastián; Irati Markuerkiaga; Jesús M. Pradillo; Makoto Higuchi; Jordi Llop; María Ángeles Moro; Abraham Martín; Ignacio Lizasoain

doi:10.1177/0271678X15627657

Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

Ana Moraga
, Vanessa Gómez-Vallejo
, María Isabel Cuartero
, Boguslaw Szczupak
, Eneko San Sebastián
, Irati Markuerkiaga
, Jesús M. Pradillo
, Makoto Higuchi
, Jordi Llop
, María Ángeles Moro
, Abraham Martín
, Ignacio Lizasoain

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

21 被引用数 (Scopus)

抄録

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[¹⁸F]fluorothymidine and [¹¹C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4^+/+ and TLR4^-/-mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[¹⁸F]fluorothymidine and [¹¹C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4^-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

本文言語	英語
ページ（範囲）	702-708
ページ数	7
ジャーナル	Journal of Cerebral Blood Flow and Metabolism
巻	36
号	4
DOI	https://doi.org/10.1177/0271678X15627657
出版ステータス	出版済み - 2015
外部発表	はい

All Science Journal Classification (ASJC) codes

神経学
臨床神経学
循環器および心血管医学

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10.1177/0271678X15627657

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引用スタイル

Moraga, A., Gómez-Vallejo, V., Cuartero, M. I., Szczupak, B., San Sebastián, E., Markuerkiaga, I., Pradillo, J. M., Higuchi, M., Llop, J., Moro, M. Á., Martín, A., & Lizasoain, I. (2015). Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. Journal of Cerebral Blood Flow and Metabolism, 36(4), 702-708. https://doi.org/10.1177/0271678X15627657

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title = "Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography",

abstract = "The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/-mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.",

author = "Ana Moraga and Vanessa G{\'o}mez-Vallejo and Cuartero, \{Mar{\'i}a Isabel\} and Boguslaw Szczupak and \{San Sebasti{\'a}n\}, Eneko and Irati Markuerkiaga and Pradillo, \{Jes{\'u}s M.\} and Makoto Higuchi and Jordi Llop and Moro, \{Mar{\'i}a {\'A}ngeles\} and Abraham Mart{\'i}n and Ignacio Lizasoain",

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Moraga, A, Gómez-Vallejo, V, Cuartero, MI, Szczupak, B, San Sebastián, E, Markuerkiaga, I, Pradillo, JM, Higuchi, M, Llop, J, Moro, MÁ, Martín, A & Lizasoain, I 2015, 'Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography', Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 4, pp. 702-708. https://doi.org/10.1177/0271678X15627657

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T1 - Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

AU - Moraga, Ana

AU - Gómez-Vallejo, Vanessa

AU - Cuartero, María Isabel

AU - Szczupak, Boguslaw

AU - San Sebastián, Eneko

AU - Markuerkiaga, Irati

AU - Pradillo, Jesús M.

AU - Higuchi, Makoto

AU - Llop, Jordi

AU - Moro, María Ángeles

AU - Martín, Abraham

AU - Lizasoain, Ignacio

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