抄録
Morphologic and immunohistochemical studies were performed to examine the existence of lymphocytes in the brain of rats. Special attention was paid to the time course of the appearance of lymphocytes in and around the pineal gland. Rabbit anti‐rat T cell and anti‐rat immunoglobulin sera were used for identification of T and B cells in tissue sections. Immunoperoxidase and immunofluorescence techniques were employed to identify cells reacting with anti‐T and anti‐immunoglobulin sera. No lymphocytes were found in the brain of rats until 20 days after birth. Small clusters of lymphocytes appeared in the pineal region by 30 days of age, after which they gradually increased in number, forming massive clusters in the pineal region by 120 days. Along with an increase in the number of lymphocytic cells, there was a gradual increase of cells reacting with anti‐T cell serum. These T cells were only a minority of pineal lymphocytes in younger animals, but 90% or more cells were stained by anti‐T cell serum at 120 days after birth. The remaining cells did not react with anti‐immunoglobulin sera either. These findings suggest that the gradual increase of T lymphocytes in the rat pineal region is a simple reflection of the normal course of maturation of T cells, and the pineal gland in the rat may have some role in immune responses within the brain.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 239-247 |
| ページ数 | 9 |
| ジャーナル | The Anatomical Record |
| 巻 | 199 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 02-1981 |
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All Science Journal Classification (ASJC) codes
- Anatomy
- Agricultural and Biological Sciences (miscellaneous)
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Immunohistochemical study of lymphocytes in rat pineal gland : Selective accumulation of T lymphocytes. / Uede, Toshimitsu; Ishii, Yoshifumi; Matsuura, Akihiro; Shimogawara, Izuru; Kikuchi, Kokichi.
：: The Anatomical Record, 巻 199, 番号 2, 02.1981, p. 239-247.研究成果: Article
TY - JOUR
T1 - Immunohistochemical study of lymphocytes in rat pineal gland
T2 - Selective accumulation of T lymphocytes
AU - Uede, Toshimitsu
AU - Ishii, Yoshifumi
AU - Matsuura, Akihiro
AU - Shimogawara, Izuru
AU - Kikuchi, Kokichi
PY - 1981/2
Y1 - 1981/2
N2 - Morphologic and immunohistochemical studies were performed to examine the existence of lymphocytes in the brain of rats. Special attention was paid to the time course of the appearance of lymphocytes in and around the pineal gland. Rabbit anti‐rat T cell and anti‐rat immunoglobulin sera were used for identification of T and B cells in tissue sections. Immunoperoxidase and immunofluorescence techniques were employed to identify cells reacting with anti‐T and anti‐immunoglobulin sera. No lymphocytes were found in the brain of rats until 20 days after birth. Small clusters of lymphocytes appeared in the pineal region by 30 days of age, after which they gradually increased in number, forming massive clusters in the pineal region by 120 days. Along with an increase in the number of lymphocytic cells, there was a gradual increase of cells reacting with anti‐T cell serum. These T cells were only a minority of pineal lymphocytes in younger animals, but 90% or more cells were stained by anti‐T cell serum at 120 days after birth. The remaining cells did not react with anti‐immunoglobulin sera either. These findings suggest that the gradual increase of T lymphocytes in the rat pineal region is a simple reflection of the normal course of maturation of T cells, and the pineal gland in the rat may have some role in immune responses within the brain.
AB - Morphologic and immunohistochemical studies were performed to examine the existence of lymphocytes in the brain of rats. Special attention was paid to the time course of the appearance of lymphocytes in and around the pineal gland. Rabbit anti‐rat T cell and anti‐rat immunoglobulin sera were used for identification of T and B cells in tissue sections. Immunoperoxidase and immunofluorescence techniques were employed to identify cells reacting with anti‐T and anti‐immunoglobulin sera. No lymphocytes were found in the brain of rats until 20 days after birth. Small clusters of lymphocytes appeared in the pineal region by 30 days of age, after which they gradually increased in number, forming massive clusters in the pineal region by 120 days. Along with an increase in the number of lymphocytic cells, there was a gradual increase of cells reacting with anti‐T cell serum. These T cells were only a minority of pineal lymphocytes in younger animals, but 90% or more cells were stained by anti‐T cell serum at 120 days after birth. The remaining cells did not react with anti‐immunoglobulin sera either. These findings suggest that the gradual increase of T lymphocytes in the rat pineal region is a simple reflection of the normal course of maturation of T cells, and the pineal gland in the rat may have some role in immune responses within the brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019454890&partnerID=8YFLogxK
U2 - 10.1002/ar.1091990208
DO - 10.1002/ar.1091990208
M3 - Article
C2 - 7011099
AN - SCOPUS:0019454890
VL - 199
SP - 239
EP - 247
JO - Anatomical Record
JF - Anatomical Record
SN - 0003-276X
IS - 2
ER -