TY - JOUR
T1 - Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD
AU - Kato, Harumi
AU - Yamamoto, Kazuhito
AU - Kodaira, Takeshi
AU - Higuchi, Yusuke
AU - Yamamoto, Hideyuki
AU - Saito, Toko
AU - Taji, Hirofumi
AU - Yatabe, Yasushi
AU - Nakamura, Shigeo
AU - Kinoshita, Tomohiro
N1 - Funding Information:
This work was supported in part by the National Cancer Center Research and Development Fund (23-A-16, 23-A-17, 26-A-4), Health and Labour Sciences Research Grant for Clinical Cancer Research (19-27, 22-29) from the Ministry of Health, Labour and Welfare, a Health and Labour Sciences Research Grant (H27-Cancer Control-Ippan-005), a grand from the Japan Agency for Medical Research and Development (AMED) (17ck0106349h0001), and a Grant-in-Aid for Aichi Cancer Center Project Research. K.Y. has received research funding from Kyowa Hakko Kirin.
Funding Information:
This work was supported in part by the National Cancer Center Research and Development Fund (23-A-16, 23-A-17, 26-A-4), Health and Labour Sciences Research Grant for Clinical Cancer Research (19-27, 22-29) from the Ministry of Health, Labour and Welfare, a Health and Labour Sciences Research Grant (H27-Cancer Control-Ippan-005), a grand from the Japan Agency for Medical Research and Development (AMED) (17ck0106349h0001), and a Grant-in-Aid for Aichi Cancer Center Project Research. K.Y. has received research funding from Kyowa Hakko Kirin. The authors thank Yasutaka Okada, Koichi Koike, and Mako Hagino for their excellent laboratory works; and Daiki Hirano for data collection. This study was presented at the 74th Annual Meeting of the Japanese Cancer Association, 8?10 October 2015.
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/2/7
Y1 - 2018/2/7
N2 - Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T (n = 2), cortical T (n = 4), and medullary T (n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.
AB - Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T (n = 2), cortical T (n = 4), and medullary T (n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.
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U2 - 10.1080/10245332.2017.1355421
DO - 10.1080/10245332.2017.1355421
M3 - Article
C2 - 28778131
AN - SCOPUS:85026873848
SN - 1024-5332
VL - 23
SP - 83
EP - 88
JO - Hematology
JF - Hematology
IS - 2
ER -