TY - JOUR
T1 - Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD
AU - Kato, Harumi
AU - Yamamoto, Kazuhito
AU - Kodaira, Takeshi
AU - Higuchi, Yusuke
AU - Yamamoto, Hideyuki
AU - Saito, Toko
AU - Taji, Hirofumi
AU - Yatabe, Yasushi
AU - Nakamura, Shigeo
AU - Kinoshita, Tomohiro
N1 - Funding Information:
This work was supported in part by the National Cancer Center Research and Development Fund (23-A-16, 23-A-17, 26-A-4), Health and Labour Sciences Research Grant for Clinical Cancer Research (19-27, 22-29) from the Ministry of Health, Labour and Welfare, a Health and Labour Sciences Research Grant (H27-Cancer Control-Ippan-005), a grand from the Japan Agency for Medical Research and Development (AMED) (17ck0106349h0001), and a Grant-in-Aid for Aichi Cancer Center Project Research. K.Y. has received research funding from Kyowa Hakko Kirin.
PY - 2018/2/7
Y1 - 2018/2/7
N2 - Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T (n = 2), cortical T (n = 4), and medullary T (n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.
AB - Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T (n = 2), cortical T (n = 4), and medullary T (n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.
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U2 - 10.1080/10245332.2017.1355421
DO - 10.1080/10245332.2017.1355421
M3 - Article
C2 - 28778131
AN - SCOPUS:85026873848
VL - 23
SP - 83
EP - 88
JO - Hematology
JF - Hematology
SN - 1024-5332
IS - 2
ER -