Immunoreactivity of VR1 on epidermal keratinocyte of human skin

Mitsuhiro Denda, Shigeyoshi Fuziwara, Kaori Inoue, Sumiko Denda, Hirohiko Akamatsu, Akiko Tomitaka, Kayoko Matsunaga

研究成果: Article

169 引用 (Scopus)

抜粋

We demonstrated the immunoreactivity of the receptor proteins, VR1, ion channels associated with pain sensation, on the epidermis of the human skin. Immunohistochemistry using antiserum against VR1 derived peptide showed immunoreactivity on the keratinocytes cell membrane of the human epidermis and cultured keratinocytes. The blocking peptide of the antiserum reduced the immunoreactivity on the epidermis. RT-PCR assay of cultured human keratinocyte also showed expression of VR1 mRNA. These results suggest the existence of VR1-like protein in epidermal keratinocytes of human skin.

元の言語English
ページ(範囲)1250-1252
ページ数3
ジャーナルBiochemical and Biophysical Research Communications
285
発行部数5
DOI
出版物ステータスPublished - 01-01-2001

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント Immunoreactivity of VR1 on epidermal keratinocyte of human skin' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用