Impact of adiponectin and leptin on long-term adverse events in Japanese patients with acute myocardial infarction: Results from the nagoya acute myocardial infarction study (NAMIS)

Yasuhiro Morita, Kengo Maeda, Takahisa Kondo, Hideki Ishii, Kyoko Matsudaira, Naoki Okumura, Hirotsugu Mitsuhashi, Rei Shibata, Toyoaki Murohara

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Background: Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear. Methods and Results: This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33-3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43-0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45-0.76), P<0.001, respectively]. The leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up in a multivariable analysis [adjusted hazard ratio 0.60 (95% CI 0.43-0.83), P=0.002]. Conclusions: Higher adiponectin and lower leptin levels are associated with a high incidence of adverse events in Japanese patients after AMI, and the leptin to adiponectin ratio independently predicts prognosis after AMI.

本文言語English
ページ(範囲)2778-2785
ページ数8
ジャーナルCirculation Journal
77
11
DOI
出版ステータスPublished - 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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