Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis

Haruki Koike, Rina Hashimoto, Minoru Tomita, Yuichi Kawagashira, Masahiro Iijima, Tomohiko Nakamura, Hirohisa Watanabe, Hideya Kamei, Tetsuya Kiuchi, Gen Sobue

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Introduction: Information related to the long-term follow-up of neuropathy in patients with familial amyloid polyneuropathy after liver transplantation is still scarce. Methods: We describe the neuropathic features of 3 patients with the transthyretin Val30Met mutation. Each patient underwent liver transplantation at an early stage of neuropathy, as indicated by the absence of motor dysfunction and relative preservation of myelinated fibers in sural nerve biopsy specimens. Results: Although the patient with late-onset disease (at age 60 years) presented with the least amount of amyloid deposition, he had neuropathic progression after liver transplantation. An older early-onset (at age 40 years) patient reported a slight exacerbation of both somatic and autonomic neuropathic symptoms 10 years after transplantation. However, the younger early-onset (at age 28 years) patient did not exhibit characteristics suggestive of neuropathy 7 years after transplantation. Conclusion: Aging may determine the progression of neuropathy after liver transplantation.

本文言語English
ページ(範囲)961-964
ページ数4
ジャーナルMuscle and Nerve
46
6
DOI
出版ステータスPublished - 12-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学
  • 臨床神経学
  • 細胞および分子神経科学
  • 生理学(医学)

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