Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients

Yusuke Izumi, Mutsuharu Hayashi, Ryota Morimoto, Xian Wu Cheng, Hongxian Wu, Hideki Ishii, Yoshinari Yasuda, Daiji Yoshikawa, Hideo Izawa, Seiichi Matsuo, Yutaka Oiso, Toyoaki Murohara

研究成果: Article

9 引用 (Scopus)

抄録

Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

元の言語English
ページ(範囲)6-14
ページ数9
ジャーナルHeart and Vessels
31
発行部数1
DOI
出版物ステータスPublished - 01-01-2016

Fingerprint

Cathepsin K
Chronic Renal Insufficiency
Coronary Vessels
Glucose Metabolism Disorders
Vascular Calcification
Cysteine Proteases

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Izumi, Yusuke ; Hayashi, Mutsuharu ; Morimoto, Ryota ; Cheng, Xian Wu ; Wu, Hongxian ; Ishii, Hideki ; Yasuda, Yoshinari ; Yoshikawa, Daiji ; Izawa, Hideo ; Matsuo, Seiichi ; Oiso, Yutaka ; Murohara, Toyoaki. / Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. :: Heart and Vessels. 2016 ; 巻 31, 番号 1. pp. 6-14.
@article{8ea980e24e1b4d7bb82b13a3e228438f,
title = "Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients",
abstract = "Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.",
author = "Yusuke Izumi and Mutsuharu Hayashi and Ryota Morimoto and Cheng, {Xian Wu} and Hongxian Wu and Hideki Ishii and Yoshinari Yasuda and Daiji Yoshikawa and Hideo Izawa and Seiichi Matsuo and Yutaka Oiso and Toyoaki Murohara",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/s00380-014-0570-z",
language = "English",
volume = "31",
pages = "6--14",
journal = "Heart and Vessels",
issn = "0910-8327",
publisher = "Springer Japan",
number = "1",

}

Izumi, Y, Hayashi, M, Morimoto, R, Cheng, XW, Wu, H, Ishii, H, Yasuda, Y, Yoshikawa, D, Izawa, H, Matsuo, S, Oiso, Y & Murohara, T 2016, 'Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients', Heart and Vessels, 巻. 31, 番号 1, pp. 6-14. https://doi.org/10.1007/s00380-014-0570-z

Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. / Izumi, Yusuke; Hayashi, Mutsuharu; Morimoto, Ryota; Cheng, Xian Wu; Wu, Hongxian; Ishii, Hideki; Yasuda, Yoshinari; Yoshikawa, Daiji; Izawa, Hideo; Matsuo, Seiichi; Oiso, Yutaka; Murohara, Toyoaki.

:: Heart and Vessels, 巻 31, 番号 1, 01.01.2016, p. 6-14.

研究成果: Article

TY - JOUR

T1 - Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients

AU - Izumi, Yusuke

AU - Hayashi, Mutsuharu

AU - Morimoto, Ryota

AU - Cheng, Xian Wu

AU - Wu, Hongxian

AU - Ishii, Hideki

AU - Yasuda, Yoshinari

AU - Yoshikawa, Daiji

AU - Izawa, Hideo

AU - Matsuo, Seiichi

AU - Oiso, Yutaka

AU - Murohara, Toyoaki

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

AB - Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

UR - http://www.scopus.com/inward/record.url?scp=84952905604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952905604&partnerID=8YFLogxK

U2 - 10.1007/s00380-014-0570-z

DO - 10.1007/s00380-014-0570-z

M3 - Article

C2 - 25150585

AN - SCOPUS:84952905604

VL - 31

SP - 6

EP - 14

JO - Heart and Vessels

JF - Heart and Vessels

SN - 0910-8327

IS - 1

ER -