Impact of HPV infection as a biomarker for head and neck carcinoma

Hisayuki Kato, Takehiro Yui, Naoki Yamamoto, Tatsuyoshi Okada, Makoto Urano, Kazuo Sakurai

研究成果: Article

抜粋

It is widely accepted that the most common risk factors for head and neck squamous cell carcinoma (HNC) are tobacco smoking and heavy alcohol consumption. Recent studies showed that an etiologic role of infection with human papillomavirus (HPV) has been implicated in the development of a subset of HNC. HPV-related HNC is associated with sexual behavior but not with tobacco smoking and alcohol drinking, and has a better prognosis with increased sensitivity to both radiation therapy and chemotherapy than HPV-unrelated HNC. Regarding molecular characteristics, immunohistochemical overexpression of p16 is observed in tumor cells with HPV-related HNC, therefore it is currently regarded as a reliable surrogate marker for HPV-related HNC. HPVrelated HNC is a clinical entity entirely distinct from HPV-unrelated HNC. This report presents an overview of the impact of HPV infection as a biomarker for head and neck carcinoma.

元の言語English
ページ(範囲)394-398
ページ数5
ジャーナルJapanese Journal of Head and Neck Cancer
38
発行部数4
DOI
出版物ステータスPublished - 01-01-2012

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology

これを引用

Kato, H., Yui, T., Yamamoto, N., Okada, T., Urano, M., & Sakurai, K. (2012). Impact of HPV infection as a biomarker for head and neck carcinoma. Japanese Journal of Head and Neck Cancer, 38(4), 394-398. https://doi.org/10.5981/jjhnc.38.394