Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients

Haruki Nishizawa, Machiko Suzuki, Kanako Pryor-Koishi, Takao Sekiya, Shin Tada, Hiroki Kurahashi, Yasuhiro Udagawa

研究成果: Article

12 引用 (Scopus)

抄録

Indoleamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of the kynurenine pathway that degrades L-tryptophan, but a wider range of functions have now been proposed for this enzyme, including antioxidant activity. Our previous study revealed that reduced IDO expression in the placenta induces defective feto-maternal immuno-tolerance leading to the onset of pre-eclampsia. In our present study, we assessed the effects of low placental IDO activity as an antioxidant. The placental levels of 8-hydroxy-2'-deoxy-guanosine (8-OHdG), a maker for oxidative damage to DNA, were significantly higher in pre-eclamptic than normotensive pregnancies (P<0.05). Immunohistochemical signals of 8-OHdG were detected mainly in syncytiotrophoblasts and vascular endothelial cells, and co-localized with those for IDO. Furthermore, a significant inverse correlation was found between the IDO activity and 8-OhdG levels. These results show that oxidative stress is associated with decreased IDO activity in the pre-eclamptic placenta and suggest an impact of low IDO activity other than immune modulation in promoting the onset of this disorder.

元の言語English
ページ(範囲)174-178
ページ数5
ジャーナルSystems Biology in Reproductive Medicine
57
発行部数4
DOI
出版物ステータスPublished - 01-08-2011

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Indoleamine-Pyrrole 2,3,-Dioxygenase
Placenta
Antioxidants
Kynurenine
Deoxyguanosine
Trophoblasts
Enzymes
Pre-Eclampsia
Tryptophan
DNA Damage
Oxidative Stress
Endothelial Cells
Mothers
Pregnancy

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Urology

これを引用

Nishizawa, Haruki ; Suzuki, Machiko ; Pryor-Koishi, Kanako ; Sekiya, Takao ; Tada, Shin ; Kurahashi, Hiroki ; Udagawa, Yasuhiro. / Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients. :: Systems Biology in Reproductive Medicine. 2011 ; 巻 57, 番号 4. pp. 174-178.
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Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients. / Nishizawa, Haruki; Suzuki, Machiko; Pryor-Koishi, Kanako; Sekiya, Takao; Tada, Shin; Kurahashi, Hiroki; Udagawa, Yasuhiro.

:: Systems Biology in Reproductive Medicine, 巻 57, 番号 4, 01.08.2011, p. 174-178.

研究成果: Article

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