TY - JOUR
T1 - Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases
T2 - A propensity-score matched and coarsened exact matched study
AU - International robotic and laparoscopic liver resection study group investigators
AU - Hoogteijling, Tijs J.
AU - Abu Hilal, Mohammad
AU - Zimmitti, Giuseppe
AU - Aghayan, Davit L.
AU - Wu, Andrew G.R.
AU - Cipriani, Federica
AU - Gruttadauria, Salvatore
AU - Scatton, Olivier
AU - Long, Tran Cong duy
AU - Herman, Paulo
AU - Marino, Marco V.
AU - Mazzaferro, Vincenzo
AU - Chiow, Adrian K.H.
AU - Sucandy, Iswanto
AU - Ivanecz, Arpad
AU - Choi, Sung Hoon
AU - Lee, Jae Hoon
AU - Gastaca, Mikel
AU - Vivarelli, Marco
AU - Giuliante, Felice
AU - Ruzzenente, Andrea
AU - Yong, Chee Chien
AU - Yin, Mengqiu
AU - Fondevila, Constantino
AU - Efanov, Mikhail
AU - Morise, Zenichi
AU - Di Benedetto, Fabrizio
AU - Brustia, Raffaele
AU - Dalla Valle, Raffaele
AU - Boggi, Ugo
AU - Geller, David
AU - Belli, Andrea
AU - Memeo, Riccardo
AU - Mejia, Alejandro
AU - Park, James O.
AU - Rotellar, Fernando
AU - Choi, Gi Hong
AU - Robles-Campos, Ricardo
AU - Wang, Xiaoying
AU - Sutcliffe, Robert P.
AU - Pratschke, Johann
AU - Tang, Chung Ngai
AU - Chong, Charing C.N.
AU - D'Hondt, Mathieu
AU - Monden, Kazuteru
AU - Lopez-Ben, Santiago
AU - Kingham, T. Peter
AU - Sugioka, Atsushi
AU - Kato, Yutaro
AU - Kojima, Masayuki
N1 - Publisher Copyright:
© 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
PY - 2024/6
Y1 - 2024/6
N2 - Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed. Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy. Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.
AB - Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed. Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy. Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.
UR - http://www.scopus.com/inward/record.url?scp=85190309567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85190309567&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2024.108309
DO - 10.1016/j.ejso.2024.108309
M3 - Article
C2 - 38626588
AN - SCOPUS:85190309567
SN - 0748-7983
VL - 50
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 6
M1 - 108309
ER -