TY - JOUR
T1 - Impact of the revision of the law on pancreatic transplants in Japan—An analysis of the Japanese Pancreas Transplants Registry
AU - Ito, Taihei
AU - Kenmochi, Takashi
AU - Aida, Naohiro
AU - Kurihara, Kei
AU - Tomimaru, Yoshito
AU - Ito, Toshinori
N1 - Funding Information:
The part of this research was funded by the Japan IDDM Network.
Funding Information:
The part of this research was funded by the Japan IDDM Network. We thanks Dr. Masaaki Watanabe and Dr. Yasuyuki Koshiduka (Hokkaido University Hospital), Dr Shigehito Miyagi and Dr. Kazuaki Tokodai (Tohoku University Hospital), Dr. Akira Kenjo and Dr. Ryo Okada (Fukushima Medical University Hospital), Dr. Keiichi Kubota and Dr. Yukihiro Iso (Dokkyo Medical University Hospital), Dr. Ichiro Nakajima and Dr. Ichiro Koyama (Tokyo Women's Medical University Hospital), Dr. Shigeyuki Kawachi and Dr. Hitoshi Iwamoto (Tokyo Medical University Hachioji Medical Center), Dr. Michihiro Maruyama and Dr. Kazunori Otsuki (National Chiba-Higashi Hospital), Dr. Toshifumi Wakai and Dr. Takashi Kobayashi (Niigata University Hospital), Dr. Shunji Narumi and Dr. Takahisa Hiramitsu (Nagoya Daini-Red Cross Hospital), Dr. Hidetaka Ushigome and Dr. Shuji Nobori (Kyoto Prefectural University Hospital), Dr. Hideaki Okajima and Dr. Takayuki Anazawa (Kyoto University Hospital), Dr. Hidetoshi Eguchi and Dr. Yoshito Tomimaru (Osaka University Hospital), Dr. Hirochika Toyama and Dr. Sachio Terai (Kobe University Hospital), Dr. Hideki Ohdan and Dr. Hiroyuki Tahara (Hiroshma University Hospital), Dr. Keiichi Okano and Dr. Minoru Oshima (Kagawa University Hospital), Dr. Tomohiko Adachi and Hajime Matsushima (Nagasaki University Hospital) and Dr. Keizo Kaku and Dr. Yasuhiro Okabe (Kyushu University Hospital) for their cooperation with the registry of Japanese Pancreas Transplantation.
Publisher Copyright:
© 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery
PY - 2021/4
Y1 - 2021/4
N2 - Background: In Japan, it has been about 10 years since the revision of the law on donating brain-dead organs. The present study compared the outcomes of pancreatic transplant before and after the revision of the law. Methods: The 437 patients who had received pancreas transplantation were divided into two groups according to the time when pancreas transplantation was performed between era 1 (before the revision) and 2 (after the revision), and compared in the patient and pancreas graft survival. Results: While the annual number of brain-dead donors was <10 in era 1, and this number significantly increased in era 2 to >50. This resulted in an increased number of pancreas transplantations: >30 cases per year. The comparison data after a propensity score-matched analysis revealed that the death-censored pancreatic graft survival at 1, 3, and 5 years after pancreas transplantation in era 2 was 94.9%, 92.0%, and 92.0%, which, while lacking significance, tended to be better than the values of 90.5%, 83.1%, and 78.2%, respectively, in era 1. Conclusions: The revision of the law on donating brain-dead organs increased the number of pancreas transplantations. Technical improvements in surgery due to increased experience with performing pancreas transplants may help improve pancreatic graft survival.
AB - Background: In Japan, it has been about 10 years since the revision of the law on donating brain-dead organs. The present study compared the outcomes of pancreatic transplant before and after the revision of the law. Methods: The 437 patients who had received pancreas transplantation were divided into two groups according to the time when pancreas transplantation was performed between era 1 (before the revision) and 2 (after the revision), and compared in the patient and pancreas graft survival. Results: While the annual number of brain-dead donors was <10 in era 1, and this number significantly increased in era 2 to >50. This resulted in an increased number of pancreas transplantations: >30 cases per year. The comparison data after a propensity score-matched analysis revealed that the death-censored pancreatic graft survival at 1, 3, and 5 years after pancreas transplantation in era 2 was 94.9%, 92.0%, and 92.0%, which, while lacking significance, tended to be better than the values of 90.5%, 83.1%, and 78.2%, respectively, in era 1. Conclusions: The revision of the law on donating brain-dead organs increased the number of pancreas transplantations. Technical improvements in surgery due to increased experience with performing pancreas transplants may help improve pancreatic graft survival.
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U2 - 10.1002/jhbp.911
DO - 10.1002/jhbp.911
M3 - Article
C2 - 33554417
AN - SCOPUS:85101607222
VL - 28
SP - 353
EP - 364
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
SN - 1868-6974
IS - 4
ER -