Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children

Tomohiko Imamura, Naokata Sumitomo, Shota Muraji, Kazushi Yasuda, Eiki Nishihara, Mari Iwamoto, Shigeru Tateno, Shozaburo Doi, Tadayoshi Hata, Shigetoyo Kogaki, Hitoshi Horigome, Seiko Ohno, Fukiko Ichida, Masami Nagashima, Takeru Makiyama, Masao Yoshinaga

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Background: T-wave inversion (TWI) is not considered useful for diagnosing pediatric arrhythmogenic right ventricular cardiomyopathy (ARVC), because right precordial TWI in ARVC resembles a normal juvenile pattern. Objectives: The aims of this study were to clarify the electrocardiographic (ECG) characteristics of pediatric ARVC to distinguish those patients from healthy children. Methods: Between 1979 and 2017, 11 ARVC patients under 18 years old were registered and compared with school screening ECGs from 48,401 healthy children. Results: The mean age at the first arrhythmic event or diagnosis was 13.3 ± 4.7 years. Nine patients were asymptomatic initially and were found by ECG screening, but 6 developed severe symptoms during the follow-up. Healthy children had a normal juvenile pattern, while ARVC children, especially symptomatic patients, had a significant tendency to have inferior and anterior TWI. The phenomenon of T-wave discontinuity (TWD) in which the TWI became deeper from V1 to V3 and suddenly turned positive in V5 was significantly more frequent in ARVC (60%) than healthy children (0.55%). Anterior TWI and TWD were also significantly more frequent in those who developed severe symptoms. The sensitivity and specificity of TWD were 60% (95% CI, 31–83%), and 99% (95% CI, 99–99%) to distinguish ARVC from healthy children, as well as 100% (95% CI, 71–100%) and 80% (95% CI, 51–80%), respectively, to predict severe symptoms in the future. Conclusions: The ECG is useful to distinguish ARVC children, even in the early phase. Anterior TWI and TWD could detect ARVC children and to predict the possible serious conditions.

本文言語English
ページ(範囲)168-174
ページ数7
ジャーナルInternational Journal of Cardiology
323
DOI
出版ステータスPublished - 15-01-2021

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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