Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

Masayuki Umemura, Kenji Hirose, Worawidh Wajjwalku, Hitoshi Nishimura, Tetsuya Matsuguchi, Yoshitaka Gotoh, Masahide Takahashi, Masahiko Makino, Yasunobu Yoshikai

研究成果: Article査読

13 被引用数 (Scopus)

抄録

LP-BM5 murine leukemia virus (MuLV) injection causes murine AIDS (MAIDS), a disease characterized by many functional abnormalities of immunocompetent cells. We show that MAIDS mice are susceptible to Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection as assessed by survival rate and bacterial counts. The peritoneal exudate macrophages from MAIDS mice produced a significant level of interleukin (IL)-12 soon after inoculation with BCG, whereas IL-15 and tumor necrosis factor (TNF) production were severely impaired in BCG-infected MAIDS mice. The appearance of natural killer (NK) and CD4+ T helper type 1 (Th1) cells specific for mycobacterial antigen were depressed in MAIDS mice after BCG infection. Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG.

本文言語English
ページ(範囲)138-148
ページ数11
ジャーナルJournal of Leukocyte Biology
69
1
出版ステータスPublished - 05-02-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 細胞生物学

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