Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle

Kiyofumi Yamada, Toshitaka Nabeshima, Tsutomu Kameyama

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Continuous infusion of quinolinic acid (QA) at low doses into the lateral ventricle has been previously shown to cause a reduction of the hippocampal and cortical ChAT activities in rats although GAD activities were unchanged. In the present study, we have studied behavioral changes in rats with continuous infusion of QA in an active avoidance task. Acquisition of active avoidance was significantly impaired in rats with QA infusion compared to control. These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairement.

本文言語English
ページ(範囲)351-355
ページ数5
ジャーナルJournal of Pharmacobio-Dynamics
14
6
DOI
出版ステータスPublished - 01-1991

All Science Journal Classification (ASJC) codes

  • Pharmacology

フィンガープリント 「Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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