Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology

Masahide Harada, Stanley Nattel

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Inflammation and fibrosis have been implicated in the pathophysiology of atrial fibrillation. Atrial fibrosis causes conduction disturbances and is a central component of atrial remodeling in atrial fibrillation. Cardiac fibroblasts, the cells responsible for fibrosis formation, are activated by inflammatory mediators and growth factors associated with systemic inflammatory conditions. Thus, inflammation contributes to atrial fibrosis; the complex interplay of these maladaptive components creates a vicious cycle of atrial remodeling progression, maintaining atrial fibrillation and increasing thrombogenicity. This review provides up-to-date knowledge regarding inflammation and fibrosis in atrial fibrillation pathophysiology and their potential as therapeutic targets.

本文言語English
ページ(範囲)25-35
ページ数11
ジャーナルCardiac Electrophysiology Clinics
13
1
DOI
出版ステータスPublished - 03-2021

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学
  • 生理学(医学)
  • 医学(全般)

フィンガープリント

「Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル