In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk, M. Hong Nguyen, Ellen G. Press, Cassaundra L. Updike, Jessica A. O'Hara, Yohei Doi, Cornelius J. Clancy, Ryan K. Shields

研究成果: Article査読

27 被引用数 (Scopus)

抄録

We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

本文言語English
ページ(範囲)1195-1199
ページ数5
ジャーナルAntimicrobial agents and chemotherapy
58
2
DOI
出版ステータスPublished - 02-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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