In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk; M. Hong Nguyen; Ellen G. Press; Cassaundra L. Updike; Jessica A. O'Hara; Yohei Doi; Cornelius J. Clancy; Ryan K. Shields

doi:10.1128/AAC.01779-13

In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk
, M. Hong Nguyen
, Ellen G. Press
, Cassaundra L. Updike
, Jessica A. O'Hara
, Yohei Doi
, Cornelius J. Clancy
, Ryan K. Shields

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

43 被引用数 (Scopus)

抄録

We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

本文言語	英語
ページ（範囲）	1195-1199
ページ数	5
ジャーナル	Antimicrobial agents and chemotherapy
巻	58
号	2
DOI	https://doi.org/10.1128/AAC.01779-13
出版ステータス	出版済み - 02-2014
外部発表	はい

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All Science Journal Classification (ASJC) codes

薬理学
薬理学（医学）
感染症

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10.1128/AAC.01779-13

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引用スタイル

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AU - Updike, Cassaundra L.

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AU - Doi, Yohei

AU - Clancy, Cornelius J.

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